One lane of the A14 was closed after a car and lorry collided near the Copdock Interchange outside of Ipswich.
The incident happened shortly before 7.20am on Monday, Suffolk police said.
A spokesman for Suffolk police said no one was injured as a result of the collision.
They added the lorry's fuel tank has ruptured – causing fuel to leak across the carriageway.
Officers on the scene used dirt from the verge to stop the fuel spreading into lane two.
In a tweet, Highways England warned the crash has caused delays of one hour on the A12 northbound and A14 eastbound.
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