Bury GP Will Ridsdill Smith, 49 and charities director Charles Mesquita, 53 from Old Newton near Stowmarket will be cycling from Land’s End to John O’Groats for the charity Bowel and Cancer Research.

The charity aims to ensure that nobody dies from bowel cancer.

While covering the distance the men will clock up 1,000 miles and climbing the height of Mt Everest in 12 days.

Mr Ridsdill Smith and Mr Mesquita will be part of a six-man team, called ‘Bums on Bikes’, who between them have pledged to raise more than £100,000 for the charity.

It won’t be the first time that Mr Mesquita has taken on a mammoth bike ride.

Mr Mesquita has been commuting to work in London by bike for 30 years and rode 700 miles with five dads from John O’Groats to his son’s school at Brandeston in Suffolk and raised £50,000 for Bowel & Cancer Research. He is now a trustee of the charity.

Mr Ridsdill Smith is also a keen cyclist and rides three miles from home in Drinkstone to his surgery in Woolpit near Bury every day.

In addition to his commute he occasionally visits patients by bike too and has had countless cycling holidays all over Europe with his family.

Mr Ridsdill Smith said :“As a GP, I see patients with bowel problems on a daily basis. The physical and psychological impact on our daily lives is huge. What better cause to be cycling for?”

The Bums on Bikes are led by company director and bowel cancer survivor Paul Reynolds, 53, from London. The challenge marks the 10th anniversary of his diagnosis of stage 3 cancer when he was 42.

Chief executive of Bowel & Cancer Research Deborah Gilbert thanked Will, Charles and the Bums on Bikes for their support.

She said:“I am always amazed at the lengths to which people will go when they have a passion for the cause.

“We will use the funds to support the best UK science working towards a day when everyone diagnosed will survive the disease.”

The dads will start their ride on June 10 and hope to be completed by June 22.

To find out more about the challenge or donate money visit www.bumsonbikes.org